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Colloidal Drug Carriers for an Anticancer Drug Paclitaxel
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UPLOADED BY-ADMIN, SIDHARTH M. PATIL, RAJENDRA C. DOIJAD
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| Abstract:
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Solid Lipid Nanoparticles (SLNs) are colloidal carriers which shown a promising utility in the delivery of various drugs
in controlled manner as well as it is having high encapsulation efficiency. Paclitaxel is a potent chemotherapeutic agent used
in the treatment of various malignancies. This chemotherapeutic agent is associated with limited bioavailability due to side
effects associated with solubilizer used in its commercial formulation and its tendency to precipitate severe side effects like
anaphylactic reaction. In this study paclitaxel solid lipid nanoparticles were prepared and were subjected to various evaluation
studies. Microemulsification method was used to prepare 3 batches of pacli-sln with different lipid concentration keeping
drug concentration unchanged. Particle size was ranged between 175-393 nm. Drug entrapment was found to be 38.90,
51.40 and 62.20 with practical yield of 45.66, 48.44 and 59.40 percent for F1, F2 and F3 batches respectively. SEM showed
spherical shape and smooth surface morphology. Release studies were carried using phosphate buffer pH 7.4, using dialysis
bag diffusion technique. At the end of 48 hrs in vitro drug release found to be 66.567 to 84.278 %. Release was found to
follow Higuchi’s classical diffusion model. Study concluded that paclitaxel loaded SLNs were stable and released the drug
for extended periode, further studies should be performed to assess the biodistribution and targetability to tumors.
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| Keyword:
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Anti- cancer drug, SLN, Paclitaxel, DPPC.
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