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Preparation and Physicochemical Characterization of Methotrexate PLGA Microparticles
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| Author:
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UPLOADED BY-ADMIN, HARSHA V PATEL, BHARAT G PATEL, VISHNU A PATEL
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| Abstract:
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The development of injectable microparticles for anticancer drug delivery is a major challenge. The
microparticles were prepared by solvent evaporation method. The physico-chemical characteristics (%
yield, drug content, t50) were affected by various parameters e.g. types of disperse phase and continuous
phase and excipients of disperse phase was studied. The % practical yield and drug content was significantly
influenced by continuous phase. In aqueous continuous phase practical yield and drug content was
very low which was improved by substitution of oily continuous phase. From in-vitro release profile %
was higher in aqueous continuous phase. It showed biphasic release pattern. The initial burst was due to
hydrophilic nature of drug and sustenance in release imparted by lipophilic nature of polymer. This modification
of drug release was obtained in appropriate combination of drug polymer ratio which was studied
preliminarily.
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| Keyword:
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Malignancy, Methotrexate (MTX), Microparticles, Solvent diffusion, PLGA
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| DOI:
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