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Identification of Potent Natural Inhibitors against H1N1/A/2009 Virus using In Silico Subtractive Genomics Approach and Docking Technology
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| Author:
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RAHUL CHAVAN, PRAMOD SHINDE, KAUSTUBH GIRKAR, RAJENDRA MANDAGE, ABHAY CHOWDHARY
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| Abstract:
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The 2009 outbreak of H1N1 pandemic killed the thousands of people from the globe. The subtractive genomics approach was used to find out the potent and unique drug target in H1N1/A/2009. Docking studies were carried using HEX, GOLD, iGEMDOCK and Autodock VINA tools and evaluation was carried out using linier regression models with the binding energy provided by the docking tools using training and testing sets. Allicin and Plumbagin were predicted as the potent multi drug targets against the Neuraminidase, Hemagglutinin and M2 protein channel of H1N1/A.
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| Keyword:
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H1N1, Subtractive genomic approach, Drug target, docking studies
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| EOI:
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| DOI:
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| Download:
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