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Formulation and evaluation of thymol loaded ethyl cellulose microparticles using solvent diffusion and nanoprecipitation methods: A comparative factorial design approach.
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| Author:
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YASHAWANT. BHALERAO
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| Abstract:
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Biodegradable polymers are widely used as drug carrier due to its properties such as better encapsulation efficiency,
controlled/sustained release action. Thymol is used for antiseptic, antibacterial, antispasmodic, antioxidant,
antimicrobial, anticancer, anti-inflammatory properties and antifungal activity. The main objective of this study is to
prepare thymol loaded ethyl cellulose nano particles using solvent diffusion and nanoprecipitation techniques. For
method optimization the statistical design approach was employed and 3 level 2 factors design was applied using
design expert (version 9.0.3.1) software. The concentration of polymer (X1) and concentration of surfactant (X2) are
considered as independent variables while percent encapsulation efficiency (Y1) and percent drug release (Y2) are as
dependent variables for both methods. The solvent diffusion technique and nanoprecipitation technique are used for
nano particles formulation to investigate suitable encapsulation technique for thymol. Obtained formulation shows
maximum 98% drug release in 10 h. Thymol loaded ethyl cellulose microparticles were successfully prepared by
solvent diffusion as well as nanoprecipitation method without any incompatibility. This study observed that
nanoprecipitation method gives quite better results than the solvent diffusion method and seems to be promising for
sustained delivery of thymol.
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| Keyword:
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Ethyl cellulose, Factorial design, Thymol, Nanoprecipitation, Solvent diffusion
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| EOI:
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http://eoi.citefactor.org/10.11209/ijpr.10.03
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.03.058
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| Download:
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