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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Formulation and evaluation of thymol loaded ethyl cellulose microparticles using solvent diffusion and nanoprecipitation methods: A comparative factorial design approach.

Author: YASHAWANT. BHALERAO
Abstract: Biodegradable polymers are widely used as drug carrier due to its properties such as better encapsulation efficiency, controlled/sustained release action. Thymol is used for antiseptic, antibacterial, antispasmodic, antioxidant, antimicrobial, anticancer, anti-inflammatory properties and antifungal activity. The main objective of this study is to prepare thymol loaded ethyl cellulose nano particles using solvent diffusion and nanoprecipitation techniques. For method optimization the statistical design approach was employed and 3 level 2 factors design was applied using design expert (version 9.0.3.1) software. The concentration of polymer (X1) and concentration of surfactant (X2) are considered as independent variables while percent encapsulation efficiency (Y1) and percent drug release (Y2) are as dependent variables for both methods. The solvent diffusion technique and nanoprecipitation technique are used for nano particles formulation to investigate suitable encapsulation technique for thymol. Obtained formulation shows maximum 98% drug release in 10 h. Thymol loaded ethyl cellulose microparticles were successfully prepared by solvent diffusion as well as nanoprecipitation method without any incompatibility. This study observed that nanoprecipitation method gives quite better results than the solvent diffusion method and seems to be promising for sustained delivery of thymol.
Keyword: Ethyl cellulose, Factorial design, Thymol, Nanoprecipitation, Solvent diffusion
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03
DOI: https://doi.org/10.31838/ijpr/2018.10.03.058
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477