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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Immunoreactivity of 36 kDa Outer Membrane Proteins (OMP) Salmonella enterica serovar Typhi as Candidate Immunodiagnostic for Typhoid Fever

Author: CUT MUTHIADIN1*, ISNA RASDIANAH AZIZ, MOCHAMMAD HATTA, MUHAMMAD NASRUM, HARTINA, DADAN SUPARDAN, ASHRIADY, DWI ELISANTI, ALINEA DWI ELISANTI5, DWI RETNA PRIHATI, EVA SARTIKA DASOPANG
Abstract: A simple, rapid and early diagnostic test for typhoid fever urgently needed for clinicians. It’s have been discovered 36 kDa OMP’s from Makassar, South Sulawesi, Indonesia. This study was aimed to determine potency of 36 KDa OMP’s to react with antibody of typhoid fever patients as candidate immunodiagnostic of typhoid fever. An OMP ‘s of S. Typhi with an apparent molecular mass of 36 kDa that is highly immunogenic, evokes humoral and cell-mediated immune responses, and confers 100% protection to immunized rats against challenge with very high doses of S. Typhi has been identified. Further, very efficient clearance of bacteria from the liver of immunized animals was seen. This protein is recognized by the antibodies present in serum of typhoid patients. The agglutination slide indicated that the immunoreactive protein evoked a strong immune response in rats. Serology test by dri-dot resulted OMP can react with serum of typhoid patients (n=25) with sensitivity 100%
Keyword: 36 kDa OMP’s S. Typhi, dri-dot, immunodiagnostic, typhoid fever
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03
DOI: https://doi.org/10.31838/ijpr/2018.10.03.067
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