IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Evaluation of Ocular electrophysiological tests in acne patients treated with isotretinoin

Author: YASAMAN OMARAEE, FARHAD ADHAMI?
Abstract: Although an effective and generally well-tolerated medication used for treatment of severe nodular acne, isotretinoin (13-cis-retinoic acid) has a broad side effect profile. The most recent study done reports the ocular side effects to be 8.96 %to investigate the effect of oral isotretinoin on retinal activity using the three different electrophysiological tests, ERG, EOG, and VEP to determine the test that can be used as a tool for follow up of patients taking this drug and detecting subclinical retinal changes.In this study 25 patients who were about to use isotretinoin in low dose (0.5 -1 mg/kg/day) for at least 4 months to treat their recalcitrant acne were chosen. Complete ophthalmologic examination including anterior and posterior segment examination, best corrected visual acuity and intraocular pressure measurement were performed at baseline before starting oral isotretinoin treatment. Patients with abnormal values were excluded from the study.The included patients underwentcomplete ophthalmologic examination and ERG, EOG and VEP tests in Basir Clinic in Tehran,6 months after they started their treatment. A comparison was made with the normal values in healthy persons in the same age through statistical tests, (One sample t-test and Spearman's correlation coefficient).A significant increase was seen in b wave latency in ERG test (p=0.05). ERG amplitude, P-100 latency and amplitudes were in the normal range. Only one patient had abnormal Arden index for EOG test. Only two patients had increased VEP latencies. We could therefore conclude that isotretinoin may adversely affect the b wave latency in ERG test, and clinicians could potentially use ERG b wave latency test as a mean for ocular follow up of patients taking isotretinoin medication for detecting the subtle subclinical retinal changes.
Keyword: Isotretinoin, ERG, EOG, VEP, Retina, Ocular electrophysiological test
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03
DOI: https://doi.org/10.31838/ijpr/2018.10.03.070
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2017CiteScore
 
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477