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Evaluation of Ocular electrophysiological tests in acne patients treated with isotretinoin
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| Author:
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YASAMAN OMARAEE, FARHAD ADHAMI?
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| Abstract:
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Although an effective and generally well-tolerated medication used for treatment of severe nodular acne, isotretinoin
(13-cis-retinoic acid) has a broad side effect profile. The most recent study done reports the ocular side effects to be
8.96 %to investigate the effect of oral isotretinoin on retinal activity using the three different electrophysiological
tests, ERG, EOG, and VEP to determine the test that can be used as a tool for follow up of patients taking this drug
and detecting subclinical retinal changes.In this study 25 patients who were about to use isotretinoin in low dose (0.5
-1 mg/kg/day) for at least 4 months to treat their recalcitrant acne were chosen. Complete ophthalmologic
examination including anterior and posterior segment examination, best corrected visual acuity and intraocular
pressure measurement were performed at baseline before starting oral isotretinoin treatment. Patients with abnormal
values were excluded from the study.The included patients underwentcomplete ophthalmologic examination and
ERG, EOG and VEP tests in Basir Clinic in Tehran,6 months after they started their treatment. A comparison was
made with the normal values in healthy persons in the same age through statistical tests, (One sample t-test and
Spearman's correlation coefficient).A significant increase was seen in b wave latency in ERG test (p=0.05). ERG
amplitude, P-100 latency and amplitudes were in the normal range. Only one patient had abnormal Arden index for
EOG test. Only two patients had increased VEP latencies. We could therefore conclude that isotretinoin may
adversely affect the b wave latency in ERG test, and clinicians could potentially use ERG b wave latency test as a mean
for ocular follow up of patients taking isotretinoin medication for detecting the subtle subclinical retinal changes.
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| Keyword:
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Isotretinoin, ERG, EOG, VEP, Retina, Ocular electrophysiological test
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| EOI:
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http://eoi.citefactor.org/10.11209/ijpr.10.03
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| DOI:
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https://doi.org/10.31838/ijpr/2018.10.03.070
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| Download:
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Request For Article
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