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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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FORMULATION OF NOVEL HERBAL CREAM AS MOSQUITO REPELLENT

Author: B. PRABASHEELA1*, V. NANDHINI, V. SAKITHYA, NIGARISH ARA, R.NAGALAKSHMI
Abstract: Vector control plays a key role in prevention and control of major vector-borne diseases. Repellents are the first line of defence against the epidemics of vector-borne diseases. Synthetic mosquito repellent used for control of vectors cause irreversible damage to ecosystem and are non-degradable in nature. The uses of biologically-active plant materials with anti-mosquitocidal properties are attracted in recent years, because of their biodegradable nature and being relatively safer to human and other non-target organism in the environment. Hence the present study aimed to produce a novel herbal cream as a mosquito repellent. The leaves included for the study are papaya (Carica papaya), Guava (Psidium guajava), Tawa tawa (Euphorbia hirta) and Neem (Azadirachta indica). The extracts were prepared by different methods such as Maceration, soxhlet and shaker extraction process and also with different solvents Ethanol, Ethyl acetate, Acetone. These extracts were qualitatively and quantitatively analysed for active ingredient. Ethyl acetate (soxhlet) was found to be high concentration of Quercetin. In vitro antioxidant properties were evaluated by reducing power assay method and ethyl acetate (soxhlet) extract were shown to posses high anti oxidant activity. This extract was chosen to formulate cream. Piperine extracted from black pepper was used as an additive in cream formulation. The prepared cream was tried on mosquitoes kept in fabricated mosquito cage. In the study it was observed that the mosquitoes moved towards the corner of the cage which indicates the repellent action. The study can be further extended to screen the toxic effect through animal studies to bring it as a potent safe and eco-friendly mosquito repellent.
Keyword: mosquito repellent, Carica papaya, Psidium guajava, Euphorbia hirta, Azadirachta indica, Quercetin, herbal cream, Piperine, repellent action, eco-friendly, biodegradable.
DOI: https://doi.org/10.31838/ijpr/2018.10.03.065
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