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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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STERCULIA QUADRIFIDA R.BR ETHYL ACETATE FRACTION INCREASES CISPLATIN CYTOTOXICITY ON T47D BREAST CANCER CELLS

Author: ROLLANDO ROLLANDO, KESTRILIA REGA PRILIANTI
Abstract: Cisplatin is a chemotherapeutic agent used as cancer cure with side effects and resistance. Ethyl acetate fraction of faloak bark (EAFB) are proven to have cytotoxic effect to cancer cells. This research aims to review the combination effect of cisplatin and EAFB to the sensitivity increase on breast cancer cells, which will be confirmed through apoptosis induction and cell cycle modulation. The cytotoxic effect was tested using MTT assay on T47D cell by using IC50 parameter. The combination was tested by determining their combination index (CI) and cell viability. The combination effect in apoptosis induction and cell cycle modulation were observed using flow cytometry method. The cytotoxic test result of the combination shows CI value of below 1 at the concentration of EAFB as much as 6 µg/mL, and cisplatin as much as 2,5 µM. The combination of EAFB and cisplatin results in phase S cell accumulation (29,98%) on breast cancer cell T47D and was able to induct apoptosis. It is proven that ethyl acetate fraction of faloak bark can be developed as a co-chemotherapeutic agent with cisplatin to increase the effectivity of breast cancer treatment
Keyword: Cisplatin, EAFB, cytoxicity, cell cycle, apoptosis
DOI: https://doi.org/10.31838/ijpr/2018.10.03.072
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