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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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OXIDATION OF QUETIAPINE BY POTASSIUM DICHROMATE IN ACID MEDIUM: A KINETIC STUDY

Author: SAYYED HUSSAIN*, SYED YOUSUFHUSSAIN, GULAM FAROOQ MUSTAFA, SAYYED SALIM
Abstract: Kinetics of oxidation of quetiapine using potassium dichromate as oxidizing agent in acid medium was studied spectrophotometrically at 520 nm. The result interprets that rate of oxidation is first order with respect to potassium dichromate and quetiapine where as it does not depend on the concentration of acid. The stoichiometry of the reaction was found that one mole of oxidant is consumed for oxidation of three moles of quetiapine and the product found is quetiapine N-oxide. From the results of kinetic studies, reaction stoichiometry and product analysis with suitable mechanism of the reaction was proposed. Based on results of the reaction at different temperatures, the activation parameters with respect to the slow step of the proposed mechanism was calculated.
Keyword: Kinetics, Oxidation, Quetiapine, Potassium Dichromate
DOI: https://doi.org/10.31838/ijpr/2018.10.03.075
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