IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Synthesis of novel (2,4-dimethoxy-3-((5-phenyl- 1,3,4-oxadiazol-2- yl)methoxy)phenyl)(phenyl)methanones and their antibacterial activity.

Author: SHASHIKANTH S, V. SRINIVASA MURTHY
Abstract: In the current study, a series of novel (2,4-dimethoxy-3-((5-phenyl-1,3,4-oxadiazol-2- yl)methoxy)phenyl)(phenyl)methanones (9a-o), were synthesized by reacting 2-(chloromethyl)- 5-phenyl-1,3,4- oxadiazole (8a-d) with aryl (3-hydroxy-2, 4-dimethoxyphenyl) methanones (4a-e) using potassium carbonate. The chemical structure of the newly synthesized compounds was characterized by analytical and spectral (1HNMR, 13CNMR and HRMS) techniques. The desired title compounds were screened for qualitative (zone of inhibition) by agar well method respectively. Among the synthesized compounds in the series, the compounds 9b, 9c, 9f and 9l were found to show major antibacterial activity at lower concentration, against Gram positive bacteria such as Bacillus subtilis, staphylococcus aureus and Gram negative bacteria such as Salmonella typhimurium Escherichia coli, Pseudomonas aeruginosa and Klebsiellapneumoniae. The rest of the compounds exhibited adequate antibacterial activity when compared to the standard positive controls Chloramphenicol.
Keyword: 2,6-dimethoxy phenol, aryl (3-hydroxy-2, 4-dimethoxyphenyl) methanones, (2,4- dimethoxy-3-((5- phenyl-1,3,4-oxadiazol-2-yl)methoxy)phenyl)(phenyl)methanone, antibacterial activity.
DOI: https://doi.org/10.31838/ijpr/2018.10.03.076
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0.07
2017CiteScore
 
11th percentile
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477