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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis of novel (2,4-dimethoxy-3-((5-phenyl- 1,3,4-oxadiazol-2- yl)methoxy)phenyl)(phenyl)methanones and their antibacterial activity.

Author: SHASHIKANTH S, V. SRINIVASA MURTHY
Abstract: In the current study, a series of novel (2,4-dimethoxy-3-((5-phenyl-1,3,4-oxadiazol-2- yl)methoxy)phenyl)(phenyl)methanones (9a-o), were synthesized by reacting 2-(chloromethyl)- 5-phenyl-1,3,4- oxadiazole (8a-d) with aryl (3-hydroxy-2, 4-dimethoxyphenyl) methanones (4a-e) using potassium carbonate. The chemical structure of the newly synthesized compounds was characterized by analytical and spectral (1HNMR, 13CNMR and HRMS) techniques. The desired title compounds were screened for qualitative (zone of inhibition) by agar well method respectively. Among the synthesized compounds in the series, the compounds 9b, 9c, 9f and 9l were found to show major antibacterial activity at lower concentration, against Gram positive bacteria such as Bacillus subtilis, staphylococcus aureus and Gram negative bacteria such as Salmonella typhimurium Escherichia coli, Pseudomonas aeruginosa and Klebsiellapneumoniae. The rest of the compounds exhibited adequate antibacterial activity when compared to the standard positive controls Chloramphenicol.
Keyword: 2,6-dimethoxy phenol, aryl (3-hydroxy-2, 4-dimethoxyphenyl) methanones, (2,4- dimethoxy-3-((5- phenyl-1,3,4-oxadiazol-2-yl)methoxy)phenyl)(phenyl)methanone, antibacterial activity.
DOI: https://doi.org/10.31838/ijpr/2018.10.03.076
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