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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effects of Liver Cancer Drugs on Cellular Energy Metabolism in Hepatocellular Carcinoma Cells

Author: MANU KANTI, SOMNATH ROY, DEBABRATA SAMANTA
Abstract: Liver cancer is the major cause of death among various types of cancer all around the world. Liver has several functions such as secretion of bile juice into the intestine for the absorption of the fats, liver is also involved in the manufacturing of the blood clotting factors that are needed to stop the bleeding. In this paper we have put an effort to study the effects of drugs which are used for the treatment of hepatocellular carcinoma cells and their influence on the metabolic pathways, specifically on aerobic glycolysis and oxygen consumption by tumour cells to meet their energy demand also we have discussed growth tumors with respect to temperature.
Keyword: ATP depletion, Glycolysis, Hepatotoxins, Hypoglysemic effect, Liver cancer, Mitochondrial inner membrane potential, Oxidative phosphorylation.
DOI: https://doi.org/10.31838/ijpr/2018.10.03.079
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0.12
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