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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The possible protective effect of Carthmustinctorius(leaves) on antituberculosis( Rifampin &Isoniazid)drugs –induced hepatotoxicity in rats.

Author: MAHDI THUWAINI, KARIM H. AL-DERAWI, HANAAS. KADHEM
Abstract: Anti-tuberculosis namely Rifampin (RIF) and Isoniazid (INH) yet represents a first-line drugs for the remedy and protection of tuberculosis disease, but various reactions frequently promote in patients administered this drug. However, Methanolic extract of leaves of Carthmustinctorius has hepatoprotective activity which was investigated against hepatotoxicity produced by administering a combination of two anti-tubercular drugs isoniazid and rifampicin.Thecurrent study was assessed the possible protective effect of Carthmustinctorius extract on antituberculosis namely (INH&RIF)drugs.So,this study was aimed at examine the possibility protect effect and mechanism of carthmustinctorius extract against (INH&RIF)drugs-induced hepatotoxicity in rats.The present study esteem the in vivo role of methanolic extract of leaves of Carthmustinctorius in protecting the liver against injury via anti-tuberculosis namely (INH&RIF)drugs in rats and further explores the underlying mechanisms. We postulate that Carthmustinctorius extract might protect the liver injury from anti-tuberculosis (INH&RIF)drugs. Moreover, forty male albino rats were haphazerdly divided into 4 groups: Control group, INH + RIF treated group, (Carthmustinctorius extract 250g/kg/daily for 28 days+ combination of RIF+ INH) treated group, and last sole of treated Carthmustinctorius extract 250g/kg/daily for 28 days. The INH + RIF were orally administered at dose levels of 50mg/ kg–b.wt., daily for 4 weeks. As well as these tissue of liverinjuries were quickly separated and fixed in 10% formalin and exposed to histopathological studies. Statistical analysis was carried out using t-test and analysis of variance (ANOVA).Administration of Antituberculosis drugs namely (RIF& INH) to rats induced marked hepatotoxicity as evidenced by significant rise in serum levels of ALT, AST, ALP and total bilirubin at (p< 0.05). The current study shows that the effectof methanolic extract of leaves of Carthmustinctoriuson some blood serum criteria of liver functions of anti- tuberculosis drugs. The study showed that relative lung weight to animals body weight was significantly increased at (P?0.05) in (RIF& INH) treated animals in comparison to the other groups. The results of present study powerfully indicated that methanolic extract of leaves of Carthmustinctorius has hepatoprotective action against RIF&INH-induced hepatic injury in rats.
Keyword: Carthmustinctorius, antituberculosis drugs, (RIF& INH), histopathological, body weight, biochemical parameters, hepatotoxicity.
DOI: https://doi.org/10.31838/ijpr/2018.10.04.083
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