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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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THE DERIVATIVE OF PRUSSIAN BLUE PAINT - KHZH90 CESIUM ISOTOPES’ SORBENT AT MYCOTOXICOSES

Author: N. KRYUKOV, V. O. YURCHENKO, A. G. KOSHCHAEV, N. E. GORKOVENKO, D. P. VINOKUROVA, A. A. BOGOSYAN, S. F. SUKHANOVA
Abstract: Experimental in vitro studies have shown that KhZh-90 ferrocyanide-bentonite sorbent of cesium isotopes has sorption properties in relation to the T-2 toxin. Feeding chickens with feedstuffs contaminated by microscopic fungi toxins leads to a deterioration in the general condition of the poultry, manifested by a decrease in appetite, increased water intake, indigestion, redness of the conjunctiva, rumpleness, and growth retardation. Morphological changes in dead birds indicate damage to the organs of detoxification (liver), excretion (kidney), digestion (intestine), immunity (spleen), lungs, and heart. Experiments found that the KhZh-90 cesium isotopes’ sorbent had positive influence on the associative mycotoxicosis in the young laying hens. The use of sorbent for chickens, when feeding them with feedstuffs contaminated by mold funghi and toxic products, leads to an increase in the viability of the poultry, and an increase in live weight gain. The KhZh-90 ferrocyanide-bentonite sorbent of cesium isotopes significantly reduced the functional and morphological manifestations of the pathological process caused by the mycotoxin association: ochratoxin A, DON, fumonisin B, zearalenone. It increased the indices of natural immunological resistance, which was expressed by an increase in the percentage of pseudoeosinophils in the leucoformula, liver detoxification, preservation of biochemical metabolic processes, increased levels of bactericidal and lysozyme activity of the blood serum and poultry survival rate.
Keyword: T-2 toxin, in vitro, mycotoxin association, ochratoxin A, DON, fumonisin B, zearalenone, chickens, PRUSSIAN blue paint, KhZh-90 cesium isotopes sorbent, natural resistance.
DOI: https://doi.org/10.31838/ijpr/2018.10.04.116
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