*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
LONG-TERM USE OF IRON-MINERAL AND IRONORGANIC DRUGS

Author: A. TROSHIN, A. N. TURCHENKO, P. D. ONISCHUK, A. G. KOSHCHAEV, S. P. KUDINOVA, A. Y. SHANTYZ, O. V. KOSHCHAEVA
Abstract: The article presents the results of a comparative laboratory study of the subacute and chronic toxicity of new ironcontaining drugs intended for farm animals. The prolonged use of ferrodrugs by injection led to a slight reversible increase in the aminotransferases activity, which indicates the hepatocytolysis phenomenon. In addition, an increase in the bilirubin and creatinine concentration in the blood has been observed, indicating the stress of the liver and kidneys performance level. On the background of the long-term intraperitoneal injection of ferro-quin, a slight decrease in the number of erythrocytes and haemoglobin has been revealed, against the background of an increase in the bilirubin concentration. However, these changes do not extend beyond the known standards. Parameters of the chronic toxicity of the studied drugs are characterized by the absence of signs of multiple organ failure. On the background of long-term ferrotherapy, the mass ratios of the internal organs of rats did not significantly differ from the control groups. The studied ferrodrugs meet the current requirements for drugs for animal husbandry and veterinary medicine in terms of subacute and chronic toxicity.
Keyword: iron salts; protein; complex, iron deficiency anemia, white mice; rats; chronic toxicity, subacute toxicity.
DOI: https://doi.org/10.31838/ijpr/2018.10.04.137
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free