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Article Detail
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Synthesis and Antibacterial Evaluation of 1,3,4- Thiadiazole Containing 1,3,4-Oxadiazole Bearing Schiff Bases.
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| Author:
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MAITHAM ABDULRIDHA,, BASSAM A. HASSAN, FADIL M.HAMED
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| Abstract:
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1,3,4-Thiadiazole and 1,3,4-Oxadiazole five-member heterocyclic which has multi bioactivity like antibacterial,
antidepressant, antidiabetic and antifungal activities. At the beginning of this study, 1,3,4-Thiadiazole containing 1,3,4-
Oxadiazole derivatives bearing Schiff bases have been synthesized(TOSB). Afterwards, The chemical structures of a
synthesized compound identified on the principles of their 1H-NMR, Ft-IR, Mass spectrum and C, H, N elemental
analysis. In time antibacterial activity of 1,3,4-Thiadiazole containing 1,3,4-Oxadiazole Bearing Schiff Base (TOSB1) and
1,3,4-Thiadiazole Bearing Schiff Base (HTSB) studied against some pathogenic bacterial strains isolated from patients
like Streptococcus, Acinetobacter, E.coli, Klebsiella,Staphylococcus, Aeromonas. Eventually, In time antibacterial
activity of 1,3,4-Thiadiazole containing 1,3,4-Oxadiazole Bearing Schiff Base (TOSB) showed a Higher biological
activity significant than 1,3,4-Thiadiazole Bearing Schiff Base (HTSB). Therefore the chemical compound(TOSB) an
important source of new antimicrobial compounds to treat bacteria.
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| Keyword:
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Antibacterial. Characterizations. Oxadiazole. Schiff bases. Syntheses. Thiadiazole.
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| DOI:
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