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Synthesis and biological activity evaluation of some new pyrazole derivatives
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| Author:
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REEM NAJM
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| Abstract:
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Mixture of p - acetophenoneand sodium hydroxide were added to ethanol followed by vanillin addition. This reactions
yield, 3-(4-hydroxy-3-methoxyphenyl)-1-(4-nitrophenyl) prop-2-en-1-one, 1-(4-chlorophenyl)-3-(4-hydroxy-3-
methoxyphenyl)prop-2-en-1-one, 1-(4-bromophenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one, and 3-(4-
hydroxy-3-methoxyphenyl)-1-(4-iodophenyl)prop-2-en-1-one. Serial other reactions were performed to synthesized
twelve other compounds which were identified by melting point, IR spectrometer, and two of them were by 1H- N.M.
R spectra. Some of the prepared compounds were evaluated for antibacterial activity which showed promising effect
as antibiotics.
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| Keyword:
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Pyrazole, Sulfonamide, Chalcones, Antibacterial, Chemicals, P – Acetophenone.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.01.083
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| Download:
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Request For Article
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