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Less Toxic Nanoparticles Of Platinum Compound For The Treatment Of Cancer
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| Author:
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MS. DEVA, DR. SHOBHNA SINGH, DR. M.M. ABDULLAHA
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| Abstract:
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The objective of this research was dose reduction and toxicity reduction. Dose reduction: various anti-cancer drugs
are very costly and their high dose increases cost. If bioavailability is enhanced, the dose shall be reduced thereby the
cost will also decrease. Dose reduction will also reduce toxicity and the preparation will become more tolerable. In
this study the nanoparticles were developed by using modified method with the drug cisplatin which was later
evaluated for stability, toxicity and therapeutic efficacy using various in-vitro and in-vivo techniques like SRB assay.
The resulting dosage form found to be more effected and less toxic then the marketed preparation of drug cisplatin
which is an i.v. injection. As cisplatin is a platinum compound and has the biggest drawback of the toxic side effects,
which is making the chemotherapy less acceptable but with preparation of nanoparticles side effects were minimized
without harming the therapeutic efficacy. Anti-cancer agents, have a number of adverse side effects and high levels of
toxicity e.g. Hair loss due to the effects on hair follicles, anaemia, immune system impairment, and clotting problems,
reduction in the number of red cells, white cells, and platelets. The nanoparticles were prepared using new generation
polymer namely EUDRAGIT. The method was self modified for the preparation of these nanoparticles. Process
optimization and validation was done before the final nanoparticles were obtained. The nanoparticles obtained were
smooth and almost round as elicited by SEM and stable more than a year as concluded from stabilities studies.
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| Keyword:
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Eudragit, Nanoparticles, anti cancer, cisplatin, chemotherapy.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.003
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| Download:
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