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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Pathogenicity of mutantAspergillusfumigatusMAFU isolate in the lung of mice during infection period

Author: SUZAN RASHID, MAYSARASAMER KHALAF, HANAA N. ABDULLAH
Abstract: The selected mutantseAspergillusfumigatus MAFUin vitro exhibited significant differences among each other and with their parents in daily radial growth rate. Regarding pathogenic activity,histopathological sections of the lungs of BALB/c strains were prepared from each mice treated and from control to be used for comparisons among the groups . Pieces from lung were fixed in 10% formalin for 1 day cut at 5 µm thickness, and20 mice were inoculated intranasal with 5*106 conidia ofemutantA.fumigatus (MAFU) in 20 ?l of PBS-0.01% Tween 20. Five mice per group were sacrificed after (7), (14) and (21) days after infection. Histopathologicaleexamination of lung after 7 days revealed severe neutrophil and macrophage infiltrate in the alveolar space with increase thickness of intra alveolar septa, and emphysema were present, hypertrophy of artery muscular layer andecongestion of blood vessel, aggregation of neutrophil in the lumen.At 14 daysepost-infection, the lung showed granulamotus lesion in the wall of bronchiole and severe and defuse aggregation of mononuclear cells and inflammatory cell in the lumen of the bronchiole, defuse with septet hyphae also shown and emphysema were present. The tissue of lung at 21 day post of infection expressed severe died and life neutrophil filled in the lumen also monocyte type 2 proliferation, also supportive exudates in the lumen of the bronchiole and erosion of the epithelial of the bronchi and epithelial layerof the bronchie.
Keyword: A.fumigatus, mutation, lung, UV, Pathogenicitye
DOI: https://doi.org/10.31838/ijpr/2019.11.02.011
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