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Role of phitofert in sperm functions and biochemical parameters of indomethacin-treated rats
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| Author:
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NAHLA M., AL-SHAHERY
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| Abstract:
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The present study aimed to investigate the underlying mechanism of reduction fertility that induced by long-term
treatment with indomethacin, also to test the capability of phitofert product to modulate of indomethacin treated
infertility. Subsequently sixty adult male rats were divided into 4 groups (15 rats each) as follows: Group1: rats were
orally administrated with physiological saline (0.9% NaCl) for 60 consecutive days (Control). Group2: rats were orally
administrated with 3 mg.Kg-1 b.w. of indomethacin for 60 consecutive days. Groups3:rats were orally administrated
with 3 mg.Kg-1 b.w. of indomethacin gathered with physiological saline for 60 consecutive days. Group4: rats were
orally administrated with 3 mg.Kg-1 b.w. of indomethacin gathered with 7 mg.Kg-1 b.w. of phitofert for 60 consecutive
days. Indomethacin-treated rats (Groups 2 and 3) in comparison with control (Group 1) showed a significant (p=0.05)
decrement in the testicular and epididymal enzymatic activity LDH-C4, ACP and the testicular steroidogenic enzyme
17ß-HSD3. Also, these groups had significant (p=0.01) decrease in the testicular and serum testosterone and
cholesterol levels. Besides, the oxidative status were noticed in the testicular and epididymal of treated group 2 and 3
representing by a significant (p=0.01) increment in the MDA levels and a significant (p=0.01) lower in the catalase
activity compared to control (Group 1). Additionally, it was noticed a significant (p=0.01) decrease in the all sperm
parameters. Our data have shown the ability of phitoferttreatment in recovery all above passive variables.
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| Keyword:
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DH-C4,3 mg.Kg-1 b.w.,(p=0.01)
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.013
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| Download:
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