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SYNTHESIS AND CHARACTERIZATION OF ISONIAZID INCORPORATED THIOFIBRATES
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| Author:
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NIRANJAN SAND
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| Abstract:
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In the present study two novel thiofibrates bearing 1, 3, 4-oxadizole and 1,2,4-triazole are prepared from isonicotinic
acid hydrazide (1). The compound (1) is on reaction with carbon disulfide in the presence of potassium hydroxide
gave 5-(pyridin-4-yl)-1,3,4-oxadiazol-2-thiol (2). This on treating with ethyl-2-bromo isobutyrate in presence of
anhydrous potassium carbonate in DMF yielded compound ethyl 2-methyl-2-[{5-(pyridin-4-yl)-1,3,4-oxadiazol-2-
yl}sulfanyl] propanoate(3). Compound 1 on further reaction with phenyl isothiocyanate in presence of sodium
hydroxide forms 4-phenyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-thiol) (4). This when treated with ethyl-2-bromo
isobutyrate under the similar conditions in obtaining compound (3) gave ethyl-2-methyl-2-{[4-phenyl-5-(pyridin-4-yl)-
4H-1,2,4-triazol-3-yl] sulfanylpropanoate (5). The progress of the reactions were monitored by TLC. The structures
of the
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| Keyword:
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Isonicotinic acid hydrazide, thiofibrate, ethyl-2-bromo isobutyrate, phenyl iso thiocyanate, carbon disulfide.
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| EOI:
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-
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| DOI:
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-
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