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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Ibudilast and OctreotideAmeliorate Acute Pancreatitis by Down Regulation of the Inflammatory and Oxidative Pathways

Author: ALAA GHAZI, SAMEER H ABOOD, HUDA GHAZI, HASSAN ALAKOULI, FATIMA GHIZAL, NAJAH HADI
Abstract: Acute pancreatitis (AP) is a severe inflammation of the pancreas that can be of 2 major types: mild AP (MAP) and severe AP (SAP). To study the therapeutic effect of Ibudilast in comparison with Octreotide, in the rat model of AP by studying inflammatory and oxidative pathways. A total of 48 male rats were divided into 8groups with each group consisting of 6 rats. Acute pancreatitis was induced by two doses of L-arginine at a dose of 250 mg/100 g of body weight intraperitoneally (IP).Octreotide and Ibudilast, their combination and their solvents were administered in separate groups at 0, 8 and 16 hours after induction. After 24 hours of treatment, blood samples were withdrawn for ELISA test to determine the interleukin-1 beta (IL-1ß) level, total antioxidant capacity (TAC) and the lipase enzyme (LPS) level. Then, extraction of the pancreas was employed for the histological examination and for gel electrophoresis to determine the extent of expression of the Nuclear Factor-Kappa B (NF-?B).
Keyword: Acute pancreatitis, inflammation, pancreas, Ibudilast, Octreotide
DOI: https://doi.org/10.31838/ijpr/2019.11.02.025
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