|
The inflammatory response to resistance training and the expression of Toll-like receptor-4 gene impact in elderly women
|
|
| Author:
|
RAWAA ALFATLAWI, TAGHREED DHEYAA ALJAZAERI, MUROOJ L. MAJEED, NAJAH R HADI
|
| Abstract:
|
Our study evaluate the effects of a resistance training scheme on the inflammationassociated with Toll-like receptor-4
expression in elderly women. Twenty healthy female (age, 60-70) were voluntarily participated,part of them were
subjected as a Training (TG; n=10), while the other parte were subjected a control (CG; n=10) group. TGperformed
a10-week resistance training program, whenCG followed theirordinary habit. sampleswere obtained from Peripheral
blood before and after the process, and levelsof TLR4expression obtained by Real time qPCR applied inthis
experiment utilized the SYBR green ,a fluorescent dye thatrecognizes any ds DNA including cDNA.The inflammatory
response was assessed throughmeasuring serum content of interleukinIL-10 and IL-6and C-reactive protein (CRP).
After the10-week exercise training, TLR4expression was decrease in TG after the intervention. While IL-6 protein
values staynot changed in both TG and CG, IL-10 protein content were increased inTG after theintervention.
However CRP values reduce in TGonly. The increase in IL-10 negatively coordinate with TLR4 down regulation.
These data proposethat resistance training may give rise toimprove the pro-inflammatory condition of old
womenthrough deficiency of TLR4 expression.
|
| Keyword:
|
Inflammation, resistanceexercise,elderly, TLR.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2019.11.02.046
|
| Download:
|
Request For Article
|
|
|