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Cutaneous Adverse Reactions Due to Dapsone and Metronidazole
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| Author:
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UPLOADED BY-ADMIN, RAGHU KUMAR V, MOHANTA GP, MANNA PK, SARVANA KUMAR RT
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| Abstract:
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Adverse drug reaction (ADRs) is a response to a drug which is noxious, unintended, which occurs at doses normally
used in human for prophylaxis or diagnosis of a disease or for modification of physiological function. No drug is absolutely
safe even when prescribed at therapeutic doses. The objective of the study is to sensitize clinicians about ADRs of drugs
during the therapy and promote safe use of medicines. We report two adverse drug reaction case reports. Firstly, Dapsone
hypersensitivity syndrome in which patient developed generalized exfoliation of skin following “MDT-MB” [Multiple drug
therapy- Multi bacillary] for 1 month. Secondly, Metronidazole induced cutaneous lesions occurred on 2nd day following
treatment for loose motions. Patient developed lesions on fore limb and hind limb. The cases were identified during ward
round participation along with clinicians. The causality assessment was made using Naranjo’s algorithm. The patient with
Dapsone syndrome was treated with Prednisolone 30mg/day for 30 days. Patient with Metronidazole induced cutaneous
lesions was treated with Prednisolone 10mg/day for 10days. Finally, Clinicians are alerted that both Dapsone and Metronidazole
has the potential to cause severe cutaneous reactions and the necessity of being alert during therapy for promoting
safe use of medication.
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| Keyword:
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Pharmacovigilance; Adverse drug reaction; Dapsone; Metronidazole.
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| EOI:
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| DOI:
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