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DEVELOPMENT AND EVALUATION OF URSOLIC ACID LOADED EUDRAGIT-E NANOCARRIER FOR CANCER THERAPY
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| Author:
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NEERAJ SETHI, PRASHANT BHARDWAJ, SANDEEP KUMAR, NEERAJ DILBAGHI
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| Abstract:
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Ursolic acid (UA), a pentacyclic triterpenoid could hinder the progression of tumor cells but its potential for clinical
utilization is significantly hampered by its poor solubility due to its hydrophobic nature. The present study is aimed to
develop a novel polymeric platform of Ursolic acid loaded Eudragit-E nanoparticles (UENPs) using nanoprecipitation
strategy. The UENPs were characterized for encapsulation potential, size, morphology, zeta potential, release rate
studies, and FTIR. The drug release profile was evaluated for in vitro antioxidant and anticancer activity. We observed
that UENPs possess particle size in the range of 18 - 35 nm and encapsulation efficiency of 59.98%. Furthermore,
Eudragit-E at 2 mg/ml and poloxamer at 0.5% w/w were competent to produce isolated and free flowing
nanoparticles. The in vitro anti-cancer assay of UENPs demonstrated inhibition of cancer cells to a greater extent and
induced programmed cell death in A-549, MCF-7 & Hela cell lines as compared to drug particles alone. These findings
suggest the utilization of UA entrapped Eudragit-E nanoparticles as advance drug delivery tool to combat cancer.
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| Keyword:
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Ursolic acid, Polymeric Nanoplatforms, Particle size, Anti-cancer activity
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.065
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| Download:
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