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Drug Design, Synthesis And Screening Of Pyrazolo Cinnoline Derivatives As Potent Anti Tubercular Agent
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| Author:
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SULTAN UNNISSA, T.K.RAVI
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| Abstract:
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Pyrazolo Cinnolines are obtained by diazotization of substituted anilines followed by coupling to form corresponding hydrazones which on Intramolecular cyclisation forms 3-acetyl- substituted-cinnolin-4-ones. Further, treatment with hydrazine hydrate yields the expected 3’-methyl-substituted-pyrazolo Cinnoline derivatives. The compounds were characterized by analytical techniques like TLC, UV, IR, NMR Spectral studies. All the synthesised compounds were checked for drug likeliness using QIKPROP software and found to be efficacious and screening for anti-tubercular activity. All the synthesised compounds shows anti tubercular activity in comparison to standard drug
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| Keyword:
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Pyrazolo Cinnoline, Cinnoline, qikprop, anti tubercular activity, MABA
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| EOI:
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-
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| DOI:
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-
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| Download:
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