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TRANSFEROSME: A NOVEL APPROACH FOR TRANSDERMAL DRUG DELIVERY SYSTEM
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| Author:
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ROOHI KESHARWANI, DILIP K PATEL, SANJAY RAJ SINGH, SURENDRA TRIPATHY
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| Abstract:
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Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of the drug occurs through the skin. It can improve the therapeutic efficacy and safety of the drugs because drug delivered through the skin at a predetermined and controlled rate. Skin is the important site of drug application for both the local and systemic effects. An average adult body covers a surface of approximately 2 m2 and receives about one-third of the blood circulating through the body. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various carriers used for transdermal systems have problem that they are only confined to skin surface. So to overcome this problem concept of rational membrane design was adopted with the development of special composite bodies so called Transferosomes. Transferosomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form, because of its deformable nature. They can act as a carrier for low as well as high molecular weight drugs e.g. analgesic, anaesthetic, corticosteroids, sex hormone, anticancer, insulin, gap junction protein, and albumin.
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| Keyword:
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Transferosomes, transdermal drug delivery, transport mechanism, skin as barrier.
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| EOI:
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| DOI:
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| Download:
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