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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Molecular Genetic Investigation of ANGPTL8 Gene in Type 2 Diabetic Patients and Its Relationship with Some Serum Lipid Profile.

Author: KADHIM MANHIL
Abstract: Diabetes is characterized by hyperglycemia due tovarious metabolic disorders of carbohydrates, proteins, lipids, water and electrolytesdue to relative or absolute lack of insulin excretion from pancreatic beta cells, disturbance in the mechanism of action of insulin or both. The existing study was carried out to explore the nearof ANGPTL8 gene in diabetic patients and its relationship with lipid profile. One hundred blood samples were collected from diabetic and normal men aged 50 to 65 years at endocrinology and diabetic center, Thi-Qar, Iraq, for ANGPTL8 gene expression and assessment of HbA1c, lipid profiles (TG, LDL and HDL) and betatrophin. The results revealed significant elevation of serum TG, LDL, HbA1c and betatrophin concentrations as well as blood ANGPTL8 gene expression level and significant decline of serum HDL concentration in diabetic patients than normal men.
Keyword: Diabetes Mellitus, LDL, HDL, ANGPTL8.
DOI: https://doi.org/10.31838/ijpr/2019.11.02.076
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