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The Study of Gleason’s Patterns in Prostatic Adenocarcinoma and Correlation with PSA Levels - An Institutional Experience
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| Author:
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SANKARALINGAM P, MANOJ REDDY P, DR.JYOTHI SINGAMSETTY, DR RAVIKUMAR RAJU
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| Abstract:
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Aim of the study: To determine the utility of PSA levels in diagnosis of Prostate carcinoma and correlation of PSA levels with Gleason pattern of on histopathology. Significance of preoperative absolute serum PSA levels with grade s of adenocarcinoma of prostate.
Materials and methods: This is retrospective study performed at tertiary care hospital during the period of May 2018 - June 2019. This study included 74 patients with the diagnosis of prostatic adenocarcinoma and all the 74 cases of prostatic adenocarcinomas were studied in detail correlating the clinical and histopathological findings. PSA Levels of all these patients were recorded.
Results: In this examination we found that all the patients of prostatic malignancy were in the more established age gathering. The mean age was 68.66 years for prostatic adenocarcinoma. PSA levels range between 50 - 100 ng/ ml. High PSA levels (> 100 ng/ ml) are seen in patients with Grade III Prostatic carcinoma (10 cases). In the present stu dy, according to Modified Gleason’s scoring system. Majority of prostatic adenocarcinomas were in grade II (42 cases) with Gleason’s score 6 (36.4 %). Most common pattern being pattern 3 and 4.
Conclusion: With these observations, the present study indicates that all cases of prostatic adenocarcinoma should be meticulously graded according to Gleason’s scoring system and preoperative PSA levels well correlated with the grade of the tumour, as it is helpful in treatment of high grade cases.
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| Keyword:
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Prostatic adenocarcinoma, Gleason’s patterns, Gleason’s score, PSA, Grade of the tumour.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.457
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| Download:
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