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Analysis and Assessment of Zidovudine Liposomal Drug Distribution System
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| Author:
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SRINIVASAN M.K, SRAVANATHI P, DR.K RAMESH, DR. J. VENKATESWARA RAO
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| Abstract:
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The drug discharge from Liposomes relies upon numerous components incorporating Liposomes composition; the kind of medication embodied and cell nature. When it is delivered a medication that typically crosses the cell membrane will enter the cell, different medications won't enter. Zidovudine is a medication with short organic half-life& narrow therapeutic index. This investigation pointed toward improving & optimizing Zidovudine liposomal formulation to develop its bio-availability. In assessment study the impact of fluctuating arrangement of lipids on assets like particle size, effectiveness of encapsulation, & release of drug were examined. The phase transition survey is carried to affirm the total connection of Zidovudine with liposome bilayer structure. Additionally, the drug release is also changed & expanded over 8 h time in whole formulations. The F3 developed as very satisfactory formulation in so far as its properties were concerned. Moreover, drug release from very satisfactory formulation (F3) is assessed through dialysis layer to obtain drug discharge.
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| Keyword:
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Thin film hydration, vitro drug, bioavailability, Liposomes
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.478
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| Download:
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