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Pomegranate Peel: Extraction, Anthelmintic Activity and Formulation of Suspension
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| Author:
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DIVESHKUMAR CHOUDHARY, AMRITA DATE, PADMINI RAVIKUMAR, RASHMI MALLYA
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| Abstract:
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Helminthiasis infestation affects over one billion people around the world every year, primarily children in developing countries. These are most commonly caused by ascariasis, trichuriasis, and hookworms. Drugs like albendazole and mebendazole have been used for decades for the prevention and treatment of the disease. However, the appearance of resistance to these drugs has made it essential to look into alternative treatment options. Pomegranate peel has traditionally been used in India as a home remedy for diarrhea. Its use as an antioxidant, anti-inflammatory, antimotility agent and antimicrobial has been reported. Hence the objective of this study was to evaluate the anthelmintic activity of the aqueous extract of pomegranate rind, Punica granatum (Family: Lythraceae), and to prepare a suspension of the same. The extract was standardized by evaluation of phenolic content, and was found to contain 177.6mg gallic acid equivalents per gram. The anthelmintic activity was evaluated using an earthworm model, for which the paralysis time and death time were measured. The extract was found to show activity comparable to a standard dose of albendazole suspension, at a concentration of 75g/ml. Suspensions of the extract were then formulated using a range of concentrations of various suspending agents, and were assessed on the basis of their redisperability and flow rate. A suspension made using 0.75% sodium alginate as the suspending agent showed the best properties.
The results show that Pomegranate peel does possess good anthelmintic activity.
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| Keyword:
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Punica granatum, anthelmintic, suspension, gallic acid
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.083
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