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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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RELATION OF mRNA EXPRESSION OF hMLH1 AND p53 GENE IN COLORECTAL CARCINOMA PATIENTS’ FAECAL

Author: RYANTO K. SITEPU, ROSDIANA NATZIR, WARSINGGIH, MOCHAMMAD HATTA, HULDANI, FAUZIAH, HARUN ACHMAD
Abstract: We reviewed many studies on the expression of MLH1 and p53 genes in stools specimen of colorectal carcinoma patients. This disease is one of the most prevalent cancer; the second highest incidence in women and third in men. Annually reaches one million cases with half of the cases are ended in death. The risk factor of this disease is genetic mutation. Through faecal specimens, analysis can be done for the detection and diagnosis of colorectal carcinoma. By analyzing the mutation and expression of genes involved in this disease pathway, including MLH1 and P53. In almost all cases of colorectal carcinoma, MLH1 found in inactive state occurs due to mutations. It is also accompanied by decreased of p53 activity as the tumor suppressor.
Keyword: MLH1, p53, Stools examination, Colorectal carcinoma
DOI: https://doi.org/10.31838/ijpr/2020.SP1.138
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