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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Assessment the Outcome of Intralesional Bleomycin Injection, dehydrated (95%) Alcohol and Combined of Them in Managements of Orofacial Vascular Malformation

Author: MUNTATHER MUHSEN HASSAN, SAMER MAJEED MOHAMMED, ZINA ALI DAILY
Abstract: Vascular anomalies (VA) are categorized into vascular tumors and malformation depending on clinical behavior and cellular kinetics. Vascular tumors are characterized by endothelial hyperplasia, and vascular malformations arise due to vascular dysmorphogenesis and exhibit normal endothelial turnover. The aim is to evaluate and liken the effectiveness and protection of the dual sclerosants and the effect of combined of them in treatment the same cases for the orofacial vascular malformation in children and adults. The medical records of forty-three patients (16 males and 27 females) with facial and oral vascular deformities treated with the bleomycin injection inside lesion or alcohol or combined of bleomycin and alcohol respectively sessions in the same cases, aged between 3 months and 44 years. Between August 2016 and June 2019 at the Dr. Samir Dental Clinics Center. The mean age of patients was 17.27?±?11.95 years (ranged from 3 months to 44 years). The treatment outcome of effectiveness of vascular malformatiom patients treated by Bleomycin (Group 1) is complete resolution in 17(85%) patients, and the same of effectiveness of vascular malformatiom patients treated by Alcohol (Group 2) is complete resolution in 16(88%). While, effectiveness is higher in vascular malformatiom patients treated by Bleomycin and Alcohol (Group 3) is complete resolution in 5 (100%) patients. And number of sessions for treatment of vascular malformatiom patients treated by Bleomycin is more number of sessions than treated by Alcohol, and lesser number of sessions of patients treated by Bleomycin and Alcohol than number of sessions of patients treated by Bleomycin. Sclerotherapy with low doses of intralesional Bleomycin and dehydrated (95%) alcohol injections under local anesthesia are simple, safe and effective treatment.
Keyword: Outcome, Intralesional Bleomycin injection, alcohol, Managements, Orofacial Vascular Malformation.
DOI: https://doi.org/10.31838/ijpr/2020.SP1.192
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