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Determination of Levofloxacin in Pure Forms and Pharmaceutical Preparations Used Molecularly Imprinted Polymers Membrane
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| Author:
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SAJA FARHAN ABDULLAH
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| Abstract:
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Liquid electrodes of polymers imprinted with levofloxacin (lev)was constructed using precipitation polymerization. The molecularly imprinted (MIP) and non imprinted (NIP) polymers were synthesized using lev as a template. In the polymerization process, vinylacetate (VA) was used as monomer ethylene glycol dimethacrylate (EGDMA) as a cross-linker and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted membranes and the non-imprinted membranes were prepared using Di B Sabacat (DBS)and Di methyl adepate (DMA)as plasticizers in PVC matrix. The slopes and detection limits of the liquid electrodes ranged from -29.03 – -20.45 mV/decade and 2×10-5M–6×10-5M, respectively and their response time was about 1 minute. The Liquid electrodes were filled with 0. 1 M standard solution of drug and their response was stable in a pH range from 1.0 to 11.0 and with good selectivity for over several species. The developed electrodes were successfully applied for the analyte determination in preparation pharmaceutical sample without any time-consuming pretreatment steps.
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| Keyword:
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Molecularly impressed electrodes, levofloxacin, potentiometric method, Vinyl acetate (VA) monomer.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.198
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| Download:
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