|
Antimalarial activity of extract and fractions of Cayratia trifolia (L.) Domin
|
|
| Author:
|
MAULANA YUSUF ALKANDAHRI, YUSUF EKA MAULANA, ANAS SUBARNAS, ALEXANDER KWARTENG, AFIAT BERBUDI
|
| Abstract:
|
Malaria remains a public health problem throughout the world including Indonesia. Approximately, 10.7 million people are reported to be living in malaria-endemic areas in Indonesia of which 261,671 cases of malaria was recorded in 2017. One of the plants empirically used as an antimalarial drug is (Cayratiatrifolia (L.) Domin). The antimalarial activity of C. trifolia extracts and fractions against Plasmodium berghei ANKA (PbA) was investigated in vivo. This experiment was carried out by Peter’s method and 32 male Balb/C mice were observed for 4 days during the process. Analysis of chemical compounds contained in C. trifolia extract was performed using liquid chromatography tandem mass spectrometry (LC-MS/MS). Furthermore, the inhibition of parasitemia was measured by conducting a sensitivity test on the antimalarial activity of each of the C. trifolia fractions and extracts. The growth of PbA in Balb/C mice was significantly inhibited (80.14%, and 64.17%, 44.94%; p <0.05) after the administration of C. trifolia (400, 200 and 100 mg / kg) leaf extract). Likewise, all fractions of C. trifolia yielded very good antimalarial activity against PbA and the ethyl acetate fraction yielded the highest activity or inhibition (84.05%). This study showed that the extracts and fractions of C. trifolia leaves can inhibit the growth of PbA in an infected Balb/C mice and therefore, C. trifolia has the potential to be considered as a novel agent for treating malaria. However, further research will be essential to elucidate the mechanism by which C. trifolia inhibits the growth of malaria parasites.
|
| Keyword:
|
Malaria, Cayratia trifolia, Antimalarial drugs, Plasmodium berghei.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.SP1.218
|
| Download:
|
Request For Article
|
|
|