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Transdermal patch formulation and evaluation for inflammation treatment.
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| Author:
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A. KHARIA, A. K. SINGHAI, R. GILHOTRA
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| Abstract:
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Amongst 20 plants recognised for its antioxidant, anti-hypertensive, vasodilator, anti-obesity, anti-hypercholesterol and anti-atherosclerotic function, Quercetin is one of the most important bioflavonoids. Free radicals, including hypertension, vascular disorders and metabolism, are a key factor in disease development. The objective of this research was to establish a transdermal drug delivery method once regular in the dosage type for Quercetin. In the presence of the plasticizer PEG, transdermal patches with controlled HPMC and ethyl cellulose releases were prepared by solvent casting techniques. For various physicochemical parameters, release of drugs (Franz cell diffusion) and skin irritation, standard procedures have been used for analysis of prepared films. The formulations were consistent in their physical features and were consistent with patching features with low water vapor absorption. The patches were hypersensitive to the skin of rats. Releases of the batches from Q1 to Q6, in vitro displayed a release of about 57.02%, 52.66%, 85.77%, 74.78%, 64.27% and 48.08% at 24 hours, respectively. The order of medication was found to be in following way; Q3 > Q4 > Q5 > Q1 > Q2 > Q6. Carrageenan-induced Paw Edema modeling code Q3 anti-inflammatory behavior decreased paw oedema to 0.24±0.020 in the fourth hour, which has been seen to be important in comparison to the 0.69±0.069 controls and the 0.20±0.024 normal Nu Patch 200 mg. In Xylene, formulation code Q3 revealed a substantial 31.16 (percent edema) of the induced mouse odem relative to 88.15 (percent edema) regulated.
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| Keyword:
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Patch, Quercetin, Flavonoids, Transdermal, Inflammation
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.167
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| Download:
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Request For Article
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