|
The Enhancement Solubility of Oral Flurbiprofen by Using Nanoemelsion as Drug Delivery System
|
|
| Author:
|
HASANAIN SHAKIR MAHMOOD, MARYAM ALAAYEDI, MOWAFAQ M. GHAREEB, MUQDAM MAHDI MOHAMMED ALI
|
| Abstract:
|
Nanotechnology in pharmaceutics can revolutionize the oral delivery mechanism which can overcome many of the limitations compared to traditional systems. Nano size particles help the scientists to control and optimum dosing which prevents dose related toxicities. Therefore, Nano emulsion has created a new opportunity to improvement solubility and bioavailability of flurbiprofen. Flurbiprofen (FBP) is a non-steroidal anti-inflammatory drugs (NSAIDs) has an analgesic and antipyretic actions. This drug belong to class II according to biopharmaceutical classification system (BCS). Drugs of class II characterised by low aqueous solubility that lead to poor oral bioavailability and absorption. The study indicate to prepare FBP Nano emulsion and characterise it. This could be enhance dissolution, solubility and stability of this drug. To build up an effective nanoemulsion, saturated solubility of FBP in different solvents, oils, surfactants and co-surfactants were measured. FBP nanoemulsion formulations were prepared using different concentration of peppermint oil as oil phase, ethanol and tween 80 as co-surfactant and surfactant respectively in different ratios. Then the stability of prepared nanoemulsion was tested by different tests like internal phase size distribution, polydispersity index, zeta potential measurement, dye miscibility test, measurement of pH, percent transmittance measurement and in vitro dissolution test. The results provide a solid evident that the nanoemulsion system is effective for enhancing the solubility and dissolution of FBP in comparison with its pure drug powder and marketed tablet.
|
| Keyword:
|
Nanoemulsion, flurbiprofen and solubility.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.SP1.248
|
| Download:
|
Request For Article
|
|
|