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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Potential Effects of Hypoglycemic and Non-Steroidal Anti-Inflammatory Drugs on Breast Cancer (MCF-7) Cell Line

Author: KHALEED J KHALEEL, ALAA ABBAS FADHEL, MAEDA H. MOHAMMAD
Abstract: Breast cancer represents the most common non-cutaneous cancer and the second disease leading to cancer death for women in the world. Anti-diabetic and NSAIDs drugs have become as potential chemo preventive agents. This study is attentive to investigate the impact of metformin as oral hypoglycemic drug on breast cancer call lines as well as the effect of NSAIDS namely aspirin and ketorolac separately and compared the outcome. In vitro method was used to investigate the influence of metformin, aspirin and ketorolac on human breast cancer cells lines MCF7 and HBL100 cell lines as normal breast tissue and both maintain with minimal essential media. The results showed 0.0025 g/ ml of aspirin inhibits significantly viability of MCF7 cell line 14.3% compared with HBL100 cell line (represents normal breast tissue )91% viable cells. In metformin cell viability 48% in MCF7 cell line at 2 mg/ml in comparison with HBL100 cell line with same concentration to be 89% availability. In case of ketorolac is only effective at high concentration of 15mg /ml which clinically not applicable. The obtained results might be useful to treat and prevent reoccurrence breast cancer with women at high risk especially aspirin drug.
Keyword: MCF7, Aspirin, Metformin, NSAIDS drugs, Breast cancer
DOI: https://doi.org/10.31838/ijpr/2020.SP1.249
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