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Synthesis, In Vitro Anticancer Activity Study of Some New Antipyrine Derivatives Containing Thiazolidin-4-One Ring
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| Author:
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SARAH H. ABDUL-KHUDHUR, RIYADH J. NAHI
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| Abstract:
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A series of new antipyrine derivatives containing thiazolidin-4-one ring system were synthesized via the cycloaddition reaction of a series of Schiff bases 1a-e with mercaptoacetic acid under reflux conditions. The structure of the new antipyrine derivatives 2a-e was confirmed by spectral data. In addition, the cytotoxic activity of the target compounds 2a-e was investigated in vitro against breast carcinoma cell line (MCF-7). In general, the bioassay results revealed that the synthesized compounds 2a-e have a promising reducing tumor growth comparison to the normal cells.
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| Keyword:
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Heterocyclic Chemistry, antipyrine, Schiff bases, thiazolidin-4-one, anticancer activity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.256
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| Download:
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