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Role of Lipid Peroxidation and Antioxidants as Biomarkers for Prostate Cancer
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| Author:
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NAJLAA ABDULAMEER ALI, ANWAR JASIB THAABAN ALMZAIEL, AMMAR JABBAR HAMAD
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| Abstract:
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Background: Prostate cancer (PCa) is the most common cancer among men in western countries.Oxidative stress (OS) is considered to be involved in the pathophysiology of prostate cancer and development.
Objective: To evaluate the OS in patients with PCa and its association with disease development.
Materials and Methods: The current study included 130 patients with prostate cancer and 65 healthy subject (control). Lipid profile was analyses by commercially kit. Malondialdehyde (MDA) was determined by the thiobarbituric acid method. prostate-specific antigen (PSA), Superoxide dismutase(SOD), glutathione peroxidase (GSH-Px) activity and 8-Hydroxydeoxyguanosine(8-OHDG) levels were determined by enzyme linked immunosorbent assay(ELISA). Plasma vitamin E levels were estimated by colorimetric method according to the Meshali and Nightingale method.
Results: Plasma TC,TG,LDL levels were significantly increased (P=.001), while HDL levels was significantly lower in PCa patients compared with control(P=.338). There were a significant increases in PSA, MDA, 8-OHdG levels and SOD activity in PCa patients compared with control (P=.001).Serum GSH-Px activity and plasma vitamin E levels were significantly decreased in PCa patients compared to control (P=.001). PSA levels were positively correlated with MDA and 8-OHdG levels in PCa patients (r=.1700, p=.0332; r=.1059, p=.0271, respectively). A negative correlation was found between PSA and LDL in PCa patients (r=-.2657, P =.0310). MDA levels were negatively correlated with erothrocytes vitamin E levels(r=-.3780,p=.0142) and GSH-Px activity (r=-.4355, p=.0048), but positively correlated with erythrocyte SOD activity (r=.5376, p=.0003) and 8-OHdG levels (r=.6366,p=.0003).
Conclusions: The results suggest an imbalance in oxidative stress and antioxidants system may lead to develop of PCa pathogenesis.
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| Keyword:
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Prostate cancer, Malondialdehyde, Oxidative stress, antioxidant.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.257
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| Download:
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