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Study of Some SNPs for PIK3CA Gene in Laryngeal Cancer Cells line (HEP-2)
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| Author:
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LUBNA SAMI ALI, NISREEN J.MOHAMMED, RANA A.GHALEB, SHAIMAA A. AL-OUBAIDY
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| Abstract:
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Mutations of the phosphatidyl-inositol 3-kinase (PI3k) Pathway in the head and neck squamous cell carcinoma ( HNSCC) may accelerate the malignant cells formation which is already genetically aberrant, resulting in further genomic aberrations in known cancer genes. The PI3KCA gene, which codes the catalytic subunit p110a, is one of the important mutated oncogenes found in human cancers and considered as a tool for diagnostic and therapeutic targets. The results of the sequence of PCR products of amplified gene PI3KCA in the hep2 cell line include three detected SNPs and were found to be previously known as rs138281424, rs1057519925, and rs751920344 for the detected G535A, G703A, and T606C, respectively. PIK3CA was a serious potential target for pathway-specific, kinase-inhibitor-based therapies in laryngeal cancer.
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| Keyword:
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Cancer, Study, line
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.299
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| Download:
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Request For Article
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