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Histological study of Toxoplasma gondii infection in brain of mice embryos
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| Author:
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LUBNA A.AL-IBRAHIMI, ADNAN W. AL-BIDERI , HABEEB W. SHUBBER
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| Abstract:
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Toxoplasma gondii is a protozoan parasite that infected broad range of animals,,. This study was aimed to isolation of T. gondii from aborted placenta of infected women and experimentally infection of female mice and follow up the histological changes that occur in the brains of her embryos. A total of 47 placenta samples were collected from The Al-Diwaniya hospital for women and children city for isolation parasite , the histological changes in mice was performed by intraperitoneal inoculation of 0.3 ml placenta suspension during the period December 2018 until November 2019. The study showed that peritoneal cavities injected in mice is efficient method to diagnosis the infection by Toxoplasmosis and The study showed the percentage of affected embryos at age 15th before pregnancy is 46.93% , the affected embryos after pregnancy 78.78%., while the percentage of affected embryos at age 18th before pregnancy is 48.88%, the affected embryos after pregnancy 77.5%
According to the different histopathological changes observed in the brain in the affected embryos from pregnant mice affected before pregnancy, degenerate and necrosis the tissues while the changes in the affected embryos from pregnant mice affected after pregnancy were in addition to tissue degeneration and necrosis, Edema and proliferation of astrocyte in the brain with foci for hemorrhage.
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| Keyword:
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Toxoplasma gondii, Placenta, mice, brain
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.402
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| Download:
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