*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Improving Prochlorperazine Profile by Formulating the Drug as Nanoemulsion Delivery System

Author: MARYAM ALAAYEDI, ASHTI SAEED, HASANAIN SHAKIR MAHMOOD
Abstract: Nanoemulsion is one of the recent promising field for research which depends on the attractive components characteristics to enhance oral drug delivery including prochloperazine (PCP) that is utilized for the management of nausea and vomiting. PCP exhibits low aqueous solubility, low absorption and low bioavailability. For these reasons, this study aims was to produce stable PCP nanoemulsions which could enhance the lipophilic PCP solubility, then its bioavailability. The solubility of PCP was determined using different vehicles to choose the optimum solubilizer for the drug in order to select the appropriate oil, surfactant and co-surfactant based on controlling HLB (hydrophilic/lipophilic balance) more than 10 to produce w/o nanoemulsion. The formulas of nanoemulsion were produced using different amount of peppermint oil, tween 80 (surfactant) and transcutol HP (co-surfactant) using titration method against water at different surfactant/co-surfactant ratios of 1:1, 2:1, 3:1, and 4:1. The produced nanoemulsion were evaluated for many tests including stability studies, droplet size and distribution, zeta potential, polydispersity index, spreadability, miscibility pH, viscosity, electroconductivity, transmittance, transmittance, scanning electron microscopy (SEM), surface tension and drug dissolution. The results found that the extant and rate of PCP release for the all formulas were significantly higher than the pure drug powder and the available marketed tablet. It is demonstrated that nanoemulsion is a promising strategy for improving PCP bioavailability as shown in the dissolution, the optimized formula released all its drug content in less than 1 hour and the pure powder exceed 2 hours and not yet released an acceptable amount of drug.
Keyword: Bioavailability, solubility, prochloperazine, nanoemulsion.
DOI: https://doi.org/10.31838/ijpr/2020.SP1.394
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free