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Characterisation and Cytotoxic potential of hyaluronic acid mediated silver nanoparticles
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| Author:
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V.M.KAYAL , LAKSHMINARAYANAN ARIVARASU, S. RAJESHKUMAR
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| Abstract:
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Introduction
Hyaluronic acid has good biocompatibility, biodegradability, and non immunogenicity. In addition, it has the ability to recognize specific receptors that are overexpressed on the surface of tumor cells, and cancer drugs can be targeted to the tumor cells to better kill them. Therefore, hyaluronic acid has attracted much attention as a drug delivery vehicle. Hyaluronic acid and derivatives as drug carriers contribute to drug thickening, sustained release, transdermal absorption, and improve drug targeting.
Aim
To evaluate and characterise hyaluronic acid mediated Silver Nanoparticle and it’s cytotoxic potential.
Materials and Method
The materials and methodology incorporated includes synthesis of NPs which includes characterisation using the FTIR Technique.Then, preparation of the Ag-NP Powder was done through centrifugation at 8000rpm the Ag-NP powder obtained was collected and stored in an airtight tube (Eppendorf).Cytotoxic assessment of the nanoparticles was done through a brine shrimp assay.
Results
The results pertaining to the assessment of cytotoxic properties of hyaluronic acid mediated nanoparticles are graphically analysed.A colour change was observed after the synthesis of Ag-NPs. The prepared particles were then characterised by a peak seen at 425 nm in UV-vis-spectroscopy.Cytotoxicity of hyaluronic acid mediated nanoparticles shows an incremental pattern with corresponding increase in concentration.
Conclusion
Observations from the study revealed that hyaluronic acid and its derivatives can be widely used in various drug delivery systems, such as nanoparticle drug delivery system, gel drug delivery system due to its effective cytotoxic potential.
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| Keyword:
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Hyaluronic acid, Cytotoxicity, Nanomedicine, Drug delivery system, Characterisation, Silver Nanoparticles
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.441
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| Download:
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