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Alpha Amylase and Alpha Glucosidase Inhibitory Activity of Lavender Oil
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| Author:
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SOWNDARYA B, ANITHA ROY, DR.LAKSHMI THANGAVELU
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| Abstract:
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Aim: To evaluate the effect of Lavandula officinalis (lavender oil) on alpha-amylase and alpha-glucosidase activity.
Materials and Methods: In vitro a--amylase inhibition was studied by the method of Bernfeld. The enzyme inhibition activity for a-glucosidase was evaluated according to the method previously reported by Shibano et al. (1997) with minor modifications. Acarbose was used as the positive control.
Results : The study showed the dose dependent a-amylase inhibitory activity of lavender oil when compared with acarbose, the positive control. A maximum inhibition of 82.23±1.51 % was achieved at a concentration of 4µL/mL of lavender oil which was comparable to that of standard acarbose, 90.96±1.81. %. The IC50 of the extract was found to be 0.36µL/ml and for Acarbose 0.69µL/ml. The maximum in vitro a – glucosidase inhibitory activity was found to be 87.79±3.73 % and 91.67±1.09 %at 4µL/ml for lavender oil and acarbose. The IC50 of the extract and acarbose were found to be 0.62µL/ml and 0.41µL/ml respectively.
Conclusion : The use of herbal extracts from medicinal plants is being propagated as a healthy alternative over synthetic chemical compounds for a variety of endocrine diseases. a--amylase and a-glucosidase inhibitory effects of lavender oil are promising for future development of antidiabetic agents.
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| Keyword:
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anti-diabetic, cytotoxicity, lavender oil, essential oil
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.446
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| Download:
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