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Antimicrobial Effect of Ferula Asafoetida against Escherichia Coli when Incorporated in Commercially Available Intracanal Medicament- Calcium Hydroxide: An In Vitro Study
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| Author:
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K. AJITH KAMATH, IFFAT NASIM
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| Abstract:
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Introduction: Ferula asafoetida is a commonly used household Indian spice. It has been also used over the ages as a natural medication for gastric, blood borne and other ailments. The phytocompound has been known to have impressive antimicrobial and antiparasitic properties.
Aim: To evaluate if Ferula asafoetida extract when incorporated into a commercially available Calcium Hydroxide Intracanal medicament shows an increased or synergistic antimicrobial activity.
Methodology: On a suitable culture media like Muller Hilton agar gel plate isolates of E.coli were cultured together. Commercially available Calcium Hydroxide intra canal medicament was then modified by incorporation of asafoetida extract. The materials in evaluation were then smeared on the cultured agar broth media and incubated at 370 degrees temperature. The zone of inhibition formed was observed and measured for both the materials in the test. Inference was drawn by comparing the zone of inhibition formed
Results: The diameter of the zone of inhibition varied ranging from 8.0±1.32 mm (p<0.05) in Ca(OH)2 alone to 9.5±1.53 mm (p<0.05) for Ca(OH)2 with Ferula asafoetida extract as compared to 12.33±7.09mm(p<0.05) for gentamicin . E Coli showed higher sensitivity to Ca(OH)2 with Ferula asafoetida extract than just the Ca(OH)2 alone.
Conclusion: Ferula asafoetida being a safe, economic and easily available natural agent can be routinely used or incorporated in intra canal medicaments for its antimicrobial synergistic activity. Further studies are required to study other properties of the plant extract.
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| Keyword:
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calcium hydroxide, E.coli, Ferula asafoetids.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.420
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| Download:
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