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Preparation and Characterisation of Gold Nanoparticles Using Cinnamon Oil and its Antimicrobial Activity against Oral Pathogens
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| Author:
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DEVIKA WARRIER E, RENE JOCHEBED. S, TRINAINA SOMAS KANDHAN, ANITHA ROY, RAJESHKUMAR S, DR. LAKSHMI THANGAVELU
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| Abstract:
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Aim: The purpose of the study is to assess the antimicrobial activity of gold nanoparticles against oral pathogens.
Materials and methods: Gold nanoparticles were synthesized by mixing the cinnamon oil extract with 10 ml of AuCl4 in a beaker which was kept in stirrer for 3-4 hours. A dark brown solution was obtained within an hour and the first set of readings was taken using the UV spectrum. The gold nanoparticles solution thus obtained was purified by repeated centrifugation at 6500 rpm for 15 min. Supernatant is discarded and the pellet is dissolved in synthesis of gold nanoparticles and was screened for its antibacterial activity by disc method.
Results: The synthesis of gold nanoparticles was confirmed by the colour change and from UV-Vis spectrum. A dark brown colour was obtained by the reaction of Au+ ions with cinnamon oil extract. The UV- visible spectrophotometer indicated a strong resonance at 500nm wavelength. The antibacterial activity results thus obtained showed more zones of inhibition for S.mutans and less zones of inhibition for S.aureus.
Conclusion: Hence, we conclude that the synthesized nanoparticles are more efficient in the drug delivery process. This approach has many advantages such as ease of synthesis and ease with which the process can be scaled up, economic viability etc. The applications of such eco-friendly nano particles in bactericidal, wound healing and other medical applications make this method potent and exciting.
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| Keyword:
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Anti-microbial, Cinnamon oil, gold, nanoparticles
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.421
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| Download:
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